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“CRISPR” Way to Cut Genes Speeds Advances in Autism
Less than three years ago, two landmark publications in Science gave researchers a quick and easy recipe for tinkering with genes.1,2 The papers described a new tool — a modified enzyme called CRISPR-CAS9 — that allows researchers to reach into the genome and snip, or substitute, DNA sequences...
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Growth Hormone Treatment Improves Social Impairments in Patients with Genetic Disorder Known to Cause Autism
A growth hormone treatment can significantly improve the social impairment associated with autism spectrum disorder (ASD) in patients with a related genetic syndrome, according to a pilot study conducted at the Icahn School of Medicine at Mount Sinai and published today on Pub Med, a public...
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Changes in Scores of Genes Contribute to Autism Risk
Small differences in as many as a thousand genes contribute to risk for autism, according to a study led by Mount Sinai researchers and the Autism Sequencing Consortium (ASC), and published today in the journal Nature. The new study examined data on several types of rare, genetic...
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The Future of Autism Genetics Should Learn From Its Past
Last month in November of 2014, my colleagues and I published two large studies that sequenced the genes or exomes of thousands of families with a history of autism1,2. These studies identified several dozen “high-confidence” autism genes that show spontaneous, harmful mutations in multiple...
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Autism and Science: A View from Across the Neural Divide
I am writing this because I am in the somewhat unusual position of not only being on the autism spectrum and fairly involved in the autism community, but also of coming from a scientific background, even if not in the field of autism (I am a retired electronics engineer with degrees in physics,...
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Evaluating the Ability of Learners with Autism to Work in Small Groups
Learners with autism do well with one on one instruction, and this is widely known. However, the provision of one-to-one instruction on a long-term basis is not efficient or realistic. Funding streams, particularly in adulthood, do not support this level of staffing. Furthermore, the ability to...
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Studies Map Gene Expression Across Brain Development
Now that genetic studies have implicated several hundred genes in autism, researchers are turning their attention to where and when in the healthy young brain these genes are expressed. The first two studies to tackle these questions appeared on November 21, 2013 in Cell. One report, led by...
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Study Finds That Autism Genes are Surprisingly Large
Enzymes called topoisomerases are crucial for the expression of extremely long genes in neurons, according to a study published 5 September in Nature1. More than one-quarter of these genes are known autism candidates, the study found. In the process of doing these analyses, the researchers...
